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To properly evaluate and select methods of treatment of any pain, including headache, we must remember that there are two systems: the nociceptive and antinociceptive. The first is a continuous chain, consisting of specific nonitseptorov, afferent conductors lemniskovye and ekstralemniskovye way, the nucleus of the reticular formation, ventral posterolateral nucleus thalamus, sensory cortex. The second system is represented at different levels of the CNS.