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When choosing an antidepressant for the treatment of tension-type headache, the physician should bear in mind that drugs in this group in addition to the antidepressant and analgesic detected and additional effects: protivotrevozhny, sedative, hypnotic, anti-panic, stimulyatorny (Mosolov SN, 1995). These effects are presented for each antidepressant differently. Thus, in the appointment of any antidepressant should be carefully analyzed not only the clinic HDN and severity of depression, but also the concomitant psychopathology and psycho-vegetative manifestations - anxiety, sleep disorders, panic attacks, asthenic manifestations, etc. Only by careful evaluation of the clinical condition of the patient possible to select appropriate therapy.