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Thus, clinical research shows sufficient effectiveness of treatment of chronic tension-type headache Prozac. Moreover, clinical efficacy is manifested not only relief of chronic tension-type headache and normalization of psychopathology, psycho-vegetative and motivational disorders. High levels of depression before treatment and a statistically significant and substantial reduction simultaneously with the reduction algicheskogo syndrome after treatment with antidepressant Prozac showed undoubted participation of depression in the pathogenesis of chronic tension-type headache.